Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMKLR1 | Q99788 | 19/20 | 0.42 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.41 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.41 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3605892 | 0.87 | ESR1 (0.40) | CMKLR1 | |
| SCHEMBL3603291 | 0.85 | ESR1 (0.41) | CMKLR1 | |
| SCHEMBL27701266 | 0.84 | CMKLR1 (0.38) | CMKLR1 | |
| SCHEMBL27721898 | 0.82 | KHK (0.39) | CMKLR1 | |
| SCHEMBL7290322 | 0.81 | CMKLR1 (0.41) | CMKLR1 | |
| SCHEMBL3176719 | 0.80 | TEAD1 (0.53) | TEAD1TEAD4TEAD2 | |
| SCHEMBL3604069 | 0.80 | TEAD1 (0.43) | TEAD1TEAD4TEAD2 | |
| SCHEMBL28772830 | 0.79 | SLC22A12 (0.39) | — | |
| SCHEMBL3604745 | 0.79 | TEAD1 (0.42) | TEAD1TEAD4TEAD2 | |
| SCHEMBL7377745 | 0.79 | SLC22A12 (0.42) | CMKLR1TEAD1TEAD4TEAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101166733-A | Pyrazole derivatives as phosphodiesterase 4 inhibitors | MEMORY PHARM CORP (US) | 2008-04-23 | — | — | CN | disclosed |