Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.42 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.42 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 8/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3176719 | 0.89 | TEAD1 (0.53) | TEAD1TEAD4TEAD2SLC22A12PDE4A | |
| SCHEMBL3604069 | 0.89 | TEAD1 (0.43) | TEAD1TEAD4TEAD2SLC22A12PDE4A | |
| SCHEMBL3604745 | 0.88 | TEAD1 (0.42) | TEAD1TEAD4TEAD2SLC22A12PDE4A | |
| SCHEMBL7970490 | 0.88 | TEAD1 (0.52) | TEAD1TEAD4TEAD2SLC22A12PDE4A | |
| SCHEMBL7379307 | 0.86 | TEAD1 (0.53) | TEAD1TEAD4TEAD2SLC22A12PDE4A | |
| SCHEMBL3605146 | 0.86 | MERTK (0.46) | TEAD1TEAD4TEAD2SLC22A12PDE4A | |
| SCHEMBL7288655 | 0.85 | SLC22A12 (0.43) | TEAD1TEAD4TEAD2SLC22A12PDE4A | |
| SCHEMBL7981717 | 0.83 | MERTK (0.44) | TEAD1TEAD4TEAD2SLC22A12PDE4A | |
| SCHEMBL7970370 | 0.82 | PDE4A (0.44) | TEAD1TEAD4TEAD2SLC22A12PDE4A | |
| SCHEMBL3593732 | 0.81 | MAPT (0.41) | TEAD1TEAD4TEAD2SLC22A12MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101166733-A | Pyrazole derivatives as phosphodiesterase 4 inhibitors | MEMORY PHARM CORP (US) | 2008-04-23 | — | — | CN | disclosed |