Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.52 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.52 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.52 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.51 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3176719 | 0.99 | TEAD1 (0.53) | TEAD1TEAD4TEAD2HCAR3SLC22A12 | |
| SCHEMBL7379307 | 0.96 | TEAD1 (0.53) | TEAD1TEAD4TEAD2HCAR3SLC22A12 | |
| Benzamide SCHEMBL27500015 | 0.90 | SLC22A12 (0.47) | TEAD1TEAD4TEAD2HCAR3SLC22A12 | |
| SCHEMBL7984231 | 0.89 | TEAD1 (0.46) | TEAD1TEAD4TEAD2HCAR3SLC22A12 | |
| SCHEMBL3604069 | 0.89 | TEAD1 (0.43) | TEAD1TEAD4TEAD2HCAR3SLC22A12 | |
| SCHEMBL7970826 | 0.88 | TEAD1 (0.47) | TEAD1TEAD4TEAD2HCAR3SLC22A12 | |
| SCHEMBL3604745 | 0.88 | TEAD1 (0.42) | TEAD1TEAD4TEAD2HCAR3SLC22A12 | |
| SCHEMBL7377745 | 0.88 | SLC22A12 (0.42) | TEAD1TEAD4TEAD2HCAR3SLC22A12 | |
| SCHEMBL27701271 | 0.88 | TEAD1 (0.42) | TEAD1TEAD4TEAD2HCAR3SLC22A12 | |
| SCHEMBL7288655 | 0.87 | SLC22A12 (0.43) | TEAD1TEAD4TEAD2HCAR3SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262040-B1 | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) | PFIZER INC | 2001-07-17 | — | — | US | claimed |
| CN-1234031-A | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the prodn. of tumor necrosis factor (TNF) | PFIZER (US) | 1999-11-03 | — | — | CN | claimed |
| US-6262040-B1 | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) | PFIZER INC | 2001-07-17 | — | — | US | disclosed |
| CN-1234031-A | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the prodn. of tumor necrosis factor (TNF) | PFIZER (US) | 1999-11-03 | — | — | CN | disclosed |