Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Ammonia Solution, Strong. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.37 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.37 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28871149 | 0.97 | MAPT (0.42) | MAPTSMN1; SMN2GALR3BLMLMNA | |
| Hydrochloric Acid SCHEMBL9748547 | 0.97 | — | — | |
| Ammonia Solution, Strong SCHEMBL28002569 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL9748760 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL194776 | 0.97 | — | — | |
| Water SCHEMBL9858909 | 0.94 | MAPT (0.44) | MAPTSMN1; SMN2GALR3BLMLMNA | |
| SCHEMBL9748138 | 0.94 | — | — | |
| SCHEMBL9748670 | 0.94 | — | — | |
| SCHEMBL193840 | 0.94 | — | — | |
| Fluoride Ion SCHEMBL1502834 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101001907-B | Ionomer Reinforced Inorganic Matrix Composites | INNOVATIVE CONSTRUCTION AND BUILDING MATERIALS | 2011-04-06 | — | — | CN | disclosed |
| CN-101001907-A | Ionomer Reinforced Inorganic Matrix Composites | INNOVATIVE CONSTR & BUILD MAT (US) | 2007-07-18 | — | — | CN | disclosed |