Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 9/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 7/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2770610 | 0.94 | TRPM8 (0.38) | NR1H4TRPM8MCHR1 | |
| SCHEMBL2773384 | 0.87 | TRPM8 (0.40) | NR1H4TRPM8 | |
| SCHEMBL2771847 | 0.87 | NR1H4 (0.41) | NR1H4TRPM8MCHR1 | |
| SCHEMBL2770027 | 0.85 | NR1H4 (0.56) | NR1H4MCHR1 | |
| SCHEMBL2770975 | 0.85 | NR1H4 (0.44) | NR1H4TRPM8 | |
| SCHEMBL2770584 | 0.81 | NR1H4 (0.54) | NR1H4MCHR1 | |
| SCHEMBL2773939 | 0.80 | NR1H4 (0.52) | NR1H4MCHR1 | |
| SCHEMBL2772608 | 0.79 | PTPN1 (0.35) | NR1H4TRPM8 | |
| SCHEMBL2772254 | 0.78 | TRPM8 (0.44) | NR1H4TRPM8 | |
| SCHEMBL2771742 | 0.78 | NR1H4 (0.43) | NR1H4TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |