Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MMP14 | P50281 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | STAT3 | P40763 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2773473 | 1.00 | KDR (0.62) | KDRMEN1MAPTKMT2ALMNA | |
| SCHEMBL2769405 | 0.99 | KDR (0.63) | KDRMEN1MAPTKMT2ALMNA | |
| SCHEMBL2769400 | 0.99 | KDR (0.63) | KDRMEN1MAPTKMT2ALMNA | |
| Iodide SCHEMBL10352304 | 0.98 | KDR (0.62) | KDRMEN1MAPTKMT2ALMNA | |
| Iodide SCHEMBL10352303 | 0.98 | KDR (0.62) | KDRMEN1MAPTKMT2ALMNA | |
| Bromide SCHEMBL2771712 | 0.90 | KDR (0.51) | KDR | |
| Bromide SCHEMBL2771464 | 0.90 | KDR (0.51) | KDR | |
| SCHEMBL2771485 | 0.89 | KDR (0.52) | KDR | |
| SCHEMBL2771487 | 0.89 | KDR (0.52) | KDR | |
| SCHEMBL17038721 | 0.87 | KDR (0.73) | KDRMEN1MAPTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1825883-B1 | Agents for coloring keratin fibers | PROCTER & GAMBLE (US) | 2010-04-14 | — | — | EP | claimed |
| US-7658770-B2 | Agents for coloring keratin fibers | THE PROCTER & GAMBLE COMPANY (US) | 2010-02-09 | — | — | US | claimed |
| US-20090165221-A1 | Agents for Coloring Keratin Fibers | WELLA OPERATIONS US, LLC | 2009-07-02 | — | — | US | claimed |
| US-7513916-B2 | Agents for coloring keratin fibers | THE PROCTER & GAMBLE COMPANY (US) | 2009-04-07 | — | — | US | claimed |
| WO-2007097930-A1 | AGENTS FOR COLORING KERATIN FIBERS | THE PROCTER & GAMBLE COMPANY (US) | 2007-08-30 | — | — | WO | claimed |
| US-20070199160-A1 | Agents for coloring keratin fibers | THE PROCTER & GAMBLE COMPANY | 2007-08-30 | — | — | US | claimed |
| EP-1825883-A1 | Agents for coloring keratin fibers | Wella Aktiengesellschaft (DE) | 2007-08-29 | — | — | EP | claimed |
| EP-1820537-A1 | Agents for coloring keratin fibers | Wella Aktiengesellschaft (DE) | 2007-08-22 | — | — | EP | claimed |
| EP-1825883-B1 | Agents for coloring keratin fibers | PROCTER & GAMBLE (US) | 2010-04-14 | — | — | EP | disclosed |
| US-7658770-B2 | Agents for coloring keratin fibers | THE PROCTER & GAMBLE COMPANY (US) | 2010-02-09 | — | — | US | disclosed |
| US-20090165221-A1 | Agents for Coloring Keratin Fibers | WELLA OPERATIONS US, LLC | 2009-07-02 | — | — | US | disclosed |
| US-7513916-B2 | Agents for coloring keratin fibers | THE PROCTER & GAMBLE COMPANY (US) | 2009-04-07 | — | — | US | disclosed |
| US-20070199160-A1 | Agents for coloring keratin fibers | THE PROCTER & GAMBLE COMPANY | 2007-08-30 | — | — | US | disclosed |
| EP-1825883-A1 | Agents for coloring keratin fibers | Wella Aktiengesellschaft (DE) | 2007-08-29 | — | — | EP | disclosed |
| EP-1820537-A1 | Agents for coloring keratin fibers | Wella Aktiengesellschaft (DE) | 2007-08-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090165221-A1 | Agents for Coloring Keratin Fibers | KRT18, IK, KRTCAP2 | KDR 4308/4885MEN1 4291/4885MAPT 781/4885 |
| US-20070199160-A1 | Agents for coloring keratin fibers | KRT18, IK, KRTCAP2 | KDR 4308/4885MEN1 4291/4885MAPT 781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.