Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27722270 | 0.87 | HDAC6 (0.39) | PLAUHDAC6HDAC8MEN1KMT2A | |
| SCHEMBL27701823 | 0.86 | HDAC6 (0.38) | PLAUHDAC6HDAC8MEN1KMT2A | |
| SCHEMBL28768873 | 0.86 | HDAC6 (0.38) | PLAUHDAC6HDAC8MEN1KMT2A | |
| SCHEMBL27722216 | 0.81 | HDAC1 (0.41) | HDAC1 | |
| SCHEMBL27701659 | 0.80 | HDAC6 (0.37) | PLAUHDAC6HDAC8MEN1KMT2A | |
| SCHEMBL27701807 | 0.79 | PLAU (0.44) | PLAUHDAC6HDAC8MEN1KMT2A | |
| SCHEMBL28772858 | 0.78 | HDAC8 (0.37) | HDAC6HDAC8MEN1KMT2AMMP1 | |
| SCHEMBL27722221 | 0.77 | HDAC1 (0.35) | HDAC1 | |
| SCHEMBL27701758 | 0.74 | PLAU (0.40) | PLAUHDAC6HDAC8MEN1KMT2A | |
| SCHEMBL27701642 | 0.73 | CHRNA7 (0.32) | HDAC6HDAC8MEN1KMT2AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101163703-B | Imidazo [1,2-A ] pyridine derivatives as Peptide Deformylase (PDF) inhibitors | NOVARTIS AG | 2010-12-15 | — | — | CN | disclosed |
| CN-101163703-A | Imidazo [1, 2-A ] pyridine derivatives as Peptide Deformylase (PDF) inhibitors | NOVARTIS AG (CH) | 2008-04-16 | — | — | CN | disclosed |