Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28768874 | 0.84 | HDAC1 (0.47) | PLAUHDAC1NR1H4GAANPC1 | |
| SCHEMBL27701903 | 0.83 | ALDH1A1 (0.42) | PLAUHDAC1NR1H4GAANPC1 | |
| SCHEMBL27701616 | 0.80 | HDAC1 (0.56) | HDAC1 | |
| SCHEMBL27701646 | 0.79 | PLAU (0.39) | PLAUHDAC1MEN1KMT2AHDAC6 | |
| SCHEMBL27701758 | 0.78 | PLAU (0.40) | PLAUHDAC1MEN1KMT2AHDAC6 | |
| SCHEMBL27701643 | 0.78 | TSHR (0.37) | PLAUHDAC1GAANPC1RAB9A | |
| SCHEMBL27722211 | 0.77 | PLAU (0.35) | PLAUGAAMEN1KMT2AHDAC6 | |
| SCHEMBL27722227 | 0.76 | NR1H4 (0.45) | PLAUHDAC1NR1H4MEN1KMT2A | |
| SCHEMBL27722214 | 0.76 | HDAC1 (0.39) | HDAC1GAANPC1RAB9AGFER | |
| SCHEMBL27722270 | 0.75 | HDAC6 (0.39) | PLAUHDAC1MEN1KMT2AHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101163703-B | Imidazo [1,2-A ] pyridine derivatives as Peptide Deformylase (PDF) inhibitors | NOVARTIS AG | 2010-12-15 | — | — | CN | disclosed |
| CN-101163703-A | Imidazo [1, 2-A ] pyridine derivatives as Peptide Deformylase (PDF) inhibitors | NOVARTIS AG (CH) | 2008-04-16 | — | — | CN | disclosed |