Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 16/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 15/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27684946 | 0.89 | HCRTR1 (0.42) | ALDH1A1HCRTR1TSHRHCRTR2GRM2 | |
| SCHEMBL27684910 | 0.88 | ALDH1A1 (0.40) | ALDH1A1HCRTR1TSHRHCRTR2GRM2 | |
| SCHEMBL27703905 | 0.87 | ALDH1A1 (0.40) | ALDH1A1HCRTR1TSHRHCRTR2GRM2 | |
| SCHEMBL27684948 | 0.85 | LSS (0.43) | ALDH1A1HCRTR1TSHRHCRTR2GRM2 | |
| SCHEMBL27704075 | 0.84 | DRD4 (0.33) | ALDH1A1 | |
| SCHEMBL27704001 | 0.84 | GRM2 (0.40) | ALDH1A1HCRTR1HCRTR2GRM2 | |
| SCHEMBL27684878 | 0.84 | ALDH1A1 (0.57) | ALDH1A1HCRTR1TSHRHCRTR2 | |
| SCHEMBL27703754 | 0.83 | BCHE (0.43) | ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL27685140 | 0.82 | HCRTR1 (0.40) | ALDH1A1HCRTR1TSHRHCRTR2GRM2 | |
| SCHEMBL27685088 | 0.82 | HCRTR1 (0.40) | ALDH1A1HCRTR1TSHRHCRTR2GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102134214-A | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA SWEDEN AB | 2011-07-27 | — | — | CN | disclosed |
| CN-101039907-B | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB | 2011-02-23 | — | — | CN | disclosed |
| CN-101039907-A | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2007-09-19 | — | — | CN | disclosed |