Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethyl Maleate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 known ✓ | Q14145 | 1/20 | 0.48 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.56 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.48 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Monomethyl Fumarate SCHEMBL11316342 | 0.93 | HCAR2 (0.55) | OR51E2CRBNFKBP5NFE2L2HCAR2 | |
| Monomethyl Fumarate SCHEMBL11316349 | 0.93 | HCAR2 (0.55) | OR51E2CRBNFKBP5NFE2L2HCAR2 | |
| Acrylic Acid Methyl Ester SCHEMBL4203174 | 0.86 | OR51E2 (0.52) | OR51E2CRBNFKBP5NFE2L2HCAR2 | |
| 2-Pyrrolidone SCHEMBL5282378 | 0.82 | OR51E2 (0.62) | OR51E2CRBNFKBP5TSHRKDM4E | |
| 2-Pyrrolidone SCHEMBL28253020 | 0.82 | OR51E2 (0.62) | OR51E2CRBNFKBP5TSHRKDM4E | |
| Caprolactam SCHEMBL28309060 | 0.80 | CRBN (0.52) | OR51E2CRBNFKBP5TSHRKDM4E | |
| 2-Pyrrolidone SCHEMBL17698402 | 0.78 | OR51E2 (0.75) | OR51E2CRBNFKBP5TSHRKDM4E | |
| 2-Pyrrolidone SCHEMBL1436788 | 0.77 | — | — | |
| Fumaric Acid SCHEMBL9716900 | 0.76 | OR51E2 (0.65) | OR51E2CRBNFKBP5TSHRKDM4E | |
| Fumaric Acid SCHEMBL9716897 | 0.76 | OR51E2 (0.65) | OR51E2CRBNFKBP5TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101849209-B | Composition for forming top anti-reflection film and pattern forming method using the same | AZ ELECTRONIC MATERIALS JAPAN | 2012-11-28 | — | — | CN | disclosed |
| CN-101849209-A | Composition for forming top anti-reflection film and pattern forming method using the same | AZ ELECTRONIC MATERIALS JAPAN | 2010-09-29 | — | — | CN | disclosed |
| CN-100587600-C | Composition for antireflection coating and pattern formation method using the same | DAINIPPON INK & CHEMICALS | 2010-02-03 | — | — | CN | disclosed |
| CN-101031846-A | Composition for antireflection coating and pattern formation method using the same | DAINIPPON INK & CHEMICALS (JP) | 2007-09-05 | — | — | CN | disclosed |