2-Pyrrolidone

2-Pyrrolidone

SCHEMBL5282378

COC(C)=O.O=C1CCCN1

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
OR51E2 Q9H255 1/20 0.62
CRBN Q96SW2 3/20 0.54
FKBP5 Q13451 1/20 0.54
ALDH1A1 P00352 3/20 0.42
KDM4E B2RXH2 2/20 0.39
GAA P10253 2/20 0.39
POLB P06746 2/20 0.39
MAPT P10636 1/20 0.36
GFER P55789 1/20 0.36
TDP1 Q9NUW8 2/20 0.33
USP2 O75604 1/20 0.33
MAPK1 P28482 1/20 0.33
HTT P42858 1/20 0.33
ABL1 P00519 1/20 0.33
RIN1 Q13671 1/20 0.33
KMT2A Q03164 1/20 0.33
TSHR P16473 2/20 0.32
PARP1 P09874 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Caprolactam SCHEMBL27561079 0.92 CRBN (0.61) OR51E2CRBNFKBP5ALDH1A1KDM4E
2-Pyrrolidone SCHEMBL28253020 0.88 OR51E2 (0.62) OR51E2CRBNFKBP5ALDH1A1KDM4E
2-Pyrrolidone SCHEMBL17698402 0.87 OR51E2 (0.75) OR51E2CRBNFKBP5ALDH1A1KDM4E
2-Pyrrolidone SCHEMBL2155488 0.85 OR51E2 (0.71) OR51E2CRBNFKBP5ALDH1A1KDM4E
2-Pyrrolidone SCHEMBL7090022 0.83 ALDH1A1 (0.52) OR51E2CRBNFKBP5ALDH1A1KDM4E
2-Pyrrolidone SCHEMBL27605240 0.83 OR51E2 (0.68) OR51E2CRBNFKBP5ALDH1A1KDM4E
2-Pyrrolidone SCHEMBL3729403 0.83 OR51E2 (0.68) OR51E2CRBNFKBP5ALDH1A1KDM4E
Dimethyl Maleate SCHEMBL27705208 0.82 OR51E2 (0.56) OR51E2CRBNFKBP5ALDH1A1KDM4E
2-Pyrrolidone SCHEMBL1436788 0.82
Ethyl Acetate SCHEMBL5493144 0.81 OR51E2 (0.54) OR51E2CRBNFKBP5ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1863761-A1 PROCESS FOR PREPARING LEVETIRACETAM Rubamin Limited (IN) 2007-12-12 EP claimed
WO-2006095362-A1 PROCESS FOR PREPARING LEVETIRACETAM RUBAMIN LIMITED (IN) 2006-09-14 WO claimed
CN-119955463-A Heat-conducting adhesive composition and preparation method thereof 江苏欧跃环保科技有限公司 2025-05-09 CN disclosed
CN-118993973-B Piracsie Synthesis method of tam 山东玉满坤生物科技有限公司 2024-12-24 CN disclosed
CN-105315190-A Method of preparing pyrrolidone acetate CHONGQING ANGE LONGXIANG PHARMACEUTICAL CO LTD 2016-02-10 CN disclosed
EP-1392696-A1 POLYMORPH FORMS OF N-(2,3-DIMETHYL-5,6,7,8-TETRAHYDROFURO 2,3-B]QUINOLIN-4-YL)-2-(2- OXOPYRROLIDIN -1 -YL)ACETAMIDE Mitsubishi Pharma Corporation (JP) 2004-03-03 EP disclosed
CN-1094485-C Process for preparing N-pyrrolidone acetate NORTHEAST PHARMACEUTICAL GENER (CN) 2002-11-20 CN disclosed
WO-2002085910-A1 POLYMORPH FORMS OF N-(2,3-DIMETHYL-5,6,7,8-TETRAHYDROFURO[2,3-B]QUINOLIN-4-YL)-2-(2- OXOPYRROLIDIN -1 -YL)ACETAMIDE MITSUBISHI PHARMA CORPORATION (JP) 2002-10-31 WO disclosed