Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 16/20 | 0.56 |
| ▸ | PPARD | Q03181 | 8/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | LIFR | P42702 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2774998 | 0.94 | NR1H4 (0.55) | NR1H4PPARDPTGDR2FFAR1PDGFRA | |
| SCHEMBL2771465 | 0.90 | NR1H4 (0.64) | NR1H4PPARDLIFR | |
| SCHEMBL2773870 | 0.89 | NR1H4 (0.55) | NR1H4PPARDFFAR1 | |
| SCHEMBL2787707 | 0.88 | NR1H4 (0.59) | NR1H4PPARDPDGFRAS1PR1ROCK1 | |
| SCHEMBL2773502 | 0.88 | NR1H4 (0.54) | NR1H4PPARD | |
| SCHEMBL2770317 | 0.87 | NR1H4 (0.68) | NR1H4LIFR | |
| SCHEMBL2773817 | 0.85 | NR1H4 (0.54) | NR1H4FFAR1 | |
| SCHEMBL2773824 | 0.85 | NR1H4 (0.56) | NR1H4PPARDPDGFRAS1PR1ROCK1 | |
| SCHEMBL2771269 | 0.84 | NR1H4 (0.56) | NR1H4PPARDFFAR1PDGFRAS1PR1 | |
| SCHEMBL2772145 | 0.84 | NR1H4 (0.51) | NR1H4PPARDFFAR1LIFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |