Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 4/20 | 0.70 |
| ▸ | TP53 | P04637 | 3/20 | 0.70 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27725989 | 0.94 | MDM2 (0.70) | MDM2TP53EPHX2MAPK1LMNA | |
| SCHEMBL3967931 | 0.89 | MDM2 (0.70) | MDM2TP53ALDH1A1SMN1; SMN2GRIN2B | |
| SCHEMBL3966847 | 0.88 | MDM2 (0.81) | MDM2TP53EPHX2MAPK1POLB | |
| SCHEMBL27705451 | 0.88 | MDM2 (0.69) | MDM2TP53EPHX2POLB | |
| SCHEMBL3971734 | 0.87 | MDM2 (0.71) | MDM2TP53LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL8248075 | 0.87 | MDM2 (0.76) | MDM2TP53EPHX2MAPK1GRIN2B | |
| SCHEMBL3964720 | 0.86 | MDM2 (0.86) | MDM2TP53GRIN2B | |
| SCHEMBL3967696 | 0.86 | MDM2 (0.77) | MDM2TP53EPHX2MAPK1LMNA | |
| SCHEMBL3964590 | 0.86 | MDM2 (0.82) | MDM2TP53 | |
| SCHEMBL3964722 | 0.85 | TP53 (0.76) | MDM2TP53LMNAALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101203489-B | Oxindole derivatives | HOFFMANN LA ROCHE | 2011-08-31 | — | — | CN | disclosed |
| CN-101203489-A | Oxindole derivatives | HOFFMANN LA ROCHE (CH) | 2008-06-18 | — | — | CN | disclosed |