Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 4/20 | 0.69 |
| ▸ | TP53 | P04637 | 2/20 | 0.69 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27725989 | 0.93 | MDM2 (0.70) | MDM2TP53EPHX1EPHX2POLB | |
| SCHEMBL3971734 | 0.89 | MDM2 (0.71) | MDM2TP53 | |
| SCHEMBL8248075 | 0.89 | MDM2 (0.76) | MDM2TP53EPHX2 | |
| SCHEMBL27705449 | 0.88 | MDM2 (0.70) | MDM2TP53EPHX2POLB | |
| SCHEMBL3967696 | 0.88 | MDM2 (0.77) | MDM2TP53EPHX2CXCR3L3MBTL1 | |
| SCHEMBL3966847 | 0.87 | MDM2 (0.81) | MDM2TP53EPHX2POLBCXCR3 | |
| SCHEMBL3967931 | 0.85 | MDM2 (0.70) | MDM2TP53 | |
| SCHEMBL3964720 | 0.85 | MDM2 (0.86) | MDM2TP53L3MBTL1 | |
| SCHEMBL3964590 | 0.84 | MDM2 (0.82) | MDM2TP53 | |
| SCHEMBL3964722 | 0.84 | TP53 (0.76) | MDM2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101203489-B | Oxindole derivatives | HOFFMANN LA ROCHE | 2011-08-31 | — | — | CN | disclosed |
| CN-101203489-A | Oxindole derivatives | HOFFMANN LA ROCHE (CH) | 2008-06-18 | — | — | CN | disclosed |