Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 18/20 | 0.63 |
| ▸ | TP53 | P04637 | 12/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27705457 | 0.91 | MDM2 (0.71) | MDM2TP53L3MBTL1 | |
| SCHEMBL3964876 | 0.87 | TP53 (0.65) | MDM2TP53 | |
| SCHEMBL3969567 | 0.84 | MDM2 (0.80) | MDM2TP53 | |
| SCHEMBL4966721 | 0.84 | MDM2 (0.70) | MDM2TP53 | |
| SCHEMBL3968027 | 0.84 | TP53 (0.71) | MDM2TP53L3MBTL1 | |
| SCHEMBL3964717 | 0.82 | MDM2 (0.68) | MDM2TP53GHSR | |
| SCHEMBL8248411 | 0.81 | MDM2 (0.67) | MDM2TP53 | |
| SCHEMBL4962890 | 0.81 | MDM2 (0.77) | MDM2TP53 | |
| SCHEMBL3970198 | 0.80 | MDM2 (0.79) | MDM2TP53L3MBTL1 | |
| SCHEMBL3969681 | 0.80 | MDM2 (0.69) | MDM2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101203489-B | Oxindole derivatives | HOFFMANN LA ROCHE | 2011-08-31 | — | — | CN | disclosed |
| CN-101203489-A | Oxindole derivatives | HOFFMANN LA ROCHE (CH) | 2008-06-18 | — | — | CN | disclosed |