Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 2/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.43 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22467840 | 0.79 | MEN1 (0.48) | MEN1KMT2AMGLLHPGDALDH1A1 | |
| SCHEMBL212176 | 0.77 | LMNA (0.57) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL28267649 | 0.76 | LMNA (0.55) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL28784449 | 0.74 | LMNA (0.53) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL3074703 | 0.74 | HPGD (0.60) | MEN1KMT2AMGLLHPGDALDH1A1 | |
| SCHEMBL27579260 | 0.73 | LMNA (0.63) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL11281806 | 0.72 | CA1 (0.46) | MEN1KMT2AMGLLHPGDALDH1A1 | |
| SCHEMBL2964437 | 0.72 | TSHR (0.48) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL29199292 | 0.72 | MEN1 (0.42) | MEN1KMT2AMGLLHPGDALDH1A1 | |
| SCHEMBL27760460 | 0.72 | MEN1 (0.42) | MEN1KMT2AMGLLHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102952112-A | Tricyclic guanidine derivatives as sodium-proton exchange inhibitors | NICHOLAS PIRAMAL INDIA LTD | 2013-03-06 | — | — | CN | disclosed |
| CN-101076525-B | Fused tricyclic compounds as inhibitors of tumor necrosis factor-alpha | NICHOLAS PIRAMAL INDIA LTD | 2011-07-27 | — | — | CN | disclosed |
| CN-101076526-A | Tricyclic guanidine derivatives as sodium-proton exchange inhibitors | NICHOLAS PIRAMAL INDIA LTD (IN) | 2007-11-21 | — | — | CN | disclosed |
| CN-101076525-A | Fused tricyclic compounds as inhibitors of tumor necrosis factor-alpha | NICHOLAS PIRAMAL INDIA LTD (IN) | 2007-11-21 | — | — | CN | disclosed |