Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 6/20 | 0.53 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.48 |
| ▸ | PKLR | P30613 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27708560 | 0.93 | HSD11B1 (0.60) | AKR1C3AKR1C1HSD11B1KMT2ATSHR | |
| SCHEMBL27708599 | 0.92 | AKR1C3 (0.57) | AKR1C3AKR1C1HSD11B1KMT2ATSHR | |
| SCHEMBL28767285 | 0.87 | AKR1C3 (0.59) | AKR1C3AKR1C1ALDH1A1MAPT | |
| SCHEMBL5243114 | 0.87 | AKR1C3 (0.67) | AKR1C3AKR1C1HSD11B1KMT2ATSHR | |
| SCHEMBL5243117 | 0.87 | AKR1C3 (0.67) | AKR1C3AKR1C1HSD11B1KMT2ATSHR | |
| SCHEMBL5244741 | 0.87 | AKR1C3 (0.67) | AKR1C3AKR1C1HSD11B1KMT2ATSHR | |
| Benzamide SCHEMBL27708563 | 0.86 | AKR1C3 (0.58) | AKR1C3AKR1C1HSD11B1KMT2ATSHR | |
| SCHEMBL1712959 | 0.86 | AKR1C3 (0.65) | AKR1C3AKR1C1HSD11B1KMT2ATSHR | |
| SCHEMBL27708609 | 0.85 | AKR1C3 (0.51) | AKR1C3AKR1C1KMT2ATSHRL3MBTL1 | |
| SCHEMBL27708524 | 0.84 | AKR1C3 (0.60) | AKR1C3AKR1C1KMT2ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101133026-B | 1- sulfonyl-pi perdine- 3 -carboxyl i c acid amide derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase for the treatment of type ii diabetes mellitus | HOFFMANN LA ROCHE | 2011-07-06 | — | — | CN | claimed |
| CN-101133026-A | 1- sulfonyl-pi perdine- 3 -carboxyl i c acid amide derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase for the treatment of type ii diabetes mellitus | HOFFMANN LA ROCHE (CH) | 2008-02-27 | — | — | CN | claimed |
| CN-101133026-B | 1- sulfonyl-pi perdine- 3 -carboxyl i c acid amide derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase for the treatment of type ii diabetes mellitus | HOFFMANN LA ROCHE | 2011-07-06 | — | — | CN | disclosed |
| CN-101133026-A | 1- sulfonyl-pi perdine- 3 -carboxyl i c acid amide derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase for the treatment of type ii diabetes mellitus | HOFFMANN LA ROCHE (CH) | 2008-02-27 | — | — | CN | disclosed |