Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 5/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.45 |
| ▸ | RXRA | P19793 | 3/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 13/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.37 |
| ▸ | USP1 | O94782 | 1/20 | 0.35 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3578836 | 0.89 | NR1H3 (0.49) | NR1H3NR1H2RXRAPTGS2PTGS1 | |
| SCHEMBL3579751 | 0.85 | NR1H2 (0.61) | NR1H3NR1H2RXRAPTGS2PTGS1 | |
| SCHEMBL27713401 | 0.82 | NR1H2 (0.46) | NR1H3NR1H2RXRAPTGS2PTGS1 | |
| SCHEMBL3576864 | 0.78 | NR1H2 (0.59) | NR1H3NR1H2RXRAPTGS2PTGS1 | |
| SCHEMBL3581954 | 0.77 | RXRA (0.65) | NR1H3NR1H2RXRAPTGS2PTGS1 | |
| SCHEMBL3581868 | 0.75 | NR1H2 (0.76) | NR1H3NR1H2RXRAPTGS2PTGS1 | |
| SCHEMBL27733838 | 0.75 | RXRA (0.41) | NR1H3NR1H2RXRAPTGS2PTGS1 | |
| SCHEMBL3583139 | 0.72 | RXRA (0.80) | NR1H3NR1H2RXRAPTGS2PTGS1 | |
| SCHEMBL3588201 | 0.71 | NR1H2 (0.62) | NR1H3NR1H2RXRAPTGS2PTGS1 | |
| SCHEMBL3585160 | 0.70 | RXRA (0.65) | NR1H3NR1H2RXRAPTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101248049-B | Imidazole based lxr modulators | EXELIXIS INC | 2013-08-28 | — | — | CN | claimed |
| CN-101248049-B | Imidazole based lxr modulators | EXELIXIS INC | 2013-08-28 | — | — | CN | disclosed |
| CN-101248049-A | Imidazole based LXR modulators | EXELIXIS INC (US) | 2008-08-20 | — | — | CN | disclosed |