Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | ARG1 | P05089 | 3/20 | 0.43 |
| ▸ | ARG2 | P78540 | 3/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.40 |
| ▸ | GRM3 | Q14832 | 3/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5651523 | 0.76 | SLC6A2 (0.50) | HRH1MEN1LMNACYP2D6SCN1A | |
| SCHEMBL7262090 | 0.75 | SMN1; SMN2 (0.53) | SMN1; SMN2HIF1AARG1ARG2GRM2 | |
| SCHEMBL28021430 | 0.74 | HRH1 (0.56) | HRH1MEN1LMNACYP2D6SCN1A | |
| SCHEMBL2358483 | 0.74 | SLC6A2 (0.39) | HRH1MEN1LMNACYP2D6SCN1A | |
| SCHEMBL27763602 | 0.74 | SMN1; SMN2 (0.51) | SMN1; SMN2HIF1AARG1ARG2GRM2 | |
| SCHEMBL7258254 | 0.74 | SMN1; SMN2 (0.51) | SMN1; SMN2HIF1AARG1ARG2GRM2 | |
| SCHEMBL1410182 | 0.74 | SMN1; SMN2 (0.51) | SMN1; SMN2HIF1AARG1ARG2GRM2 | |
| SCHEMBL5650003 | 0.73 | GBA1 (0.45) | HRH1MEN1LMNACYP2D6SCN1A | |
| SCHEMBL5310845 | 0.72 | HRH1 (0.43) | HRH1MEN1LMNACYP2D6SCN1A | |
| SCHEMBL11861949 | 0.72 | HRH1 (0.53) | HRH1MEN1LMNACYP2D6SCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101217958-A | Inhibitors of AKT activity | MERCK & CO INC (US) | 2008-07-09 | — | — | CN | claimed |
| CN-101217958-A | Inhibitors of AKT activity | MERCK & CO INC (US) | 2008-07-09 | — | — | CN | disclosed |