Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | SCN1A | P35498 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2358483 | 0.81 | SLC6A2 (0.39) | HRH1MEN1LMNACYP2D6SCN1A | |
| SCHEMBL28021430 | 0.73 | HRH1 (0.56) | HRH1MEN1LMNACYP2D6SCN1A | |
| SCHEMBL27714822 | 0.72 | HRH1 (0.44) | HRH1MEN1LMNACYP2D6SCN1A | |
| SCHEMBL4720825 | 0.72 | MEN1 (0.54) | HRH1MEN1LMNACYP2D6SCN1A | |
| SCHEMBL11861949 | 0.71 | HRH1 (0.53) | HRH1MEN1LMNACYP2D6SCN1A | |
| SCHEMBL9978781 | 0.70 | GBA1 (0.50) | HRH1MEN1LMNACYP2D6SCN1A | |
| Hydrochloric Acid SCHEMBL11843236 | 0.70 | HRH1 (0.51) | HRH1MEN1LMNACYP2D6SCN1A | |
| SCHEMBL5651523 | 0.69 | SLC6A2 (0.50) | HRH1MEN1LMNACYP2D6SCN1A | |
| Trifluoroacetic Acid SCHEMBL27730411 | 0.69 | SLC6A2 (0.52) | HRH1ITGB3ITGA2BSLC6A2SLC6A4 | |
| SCHEMBL1477277 | 0.67 | GBA1 (0.50) | HRH1MEN1LMNACYP2D6SCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805141-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LTD. (GB) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006043064-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2006-04-27 | — | — | WO | disclosed |