Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 2/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28771122 | 0.95 | MAPK13 (0.41) | MAPK13MAPK11CYP2C9MEN1KMT2A | |
| SCHEMBL4243533 | 0.89 | MAPK13 (0.53) | MAPK13MAPK11CYP2C9MEN1KMT2A | |
| SCHEMBL4236904 | 0.84 | MAPK13 (0.52) | MAPK13MAPK11CYP2C9MEN1KMT2A | |
| SCHEMBL4246034 | 0.78 | MAPK13 (0.48) | MAPK13MAPK11CYP2C9MEN1KMT2A | |
| SCHEMBL27819208 | 0.73 | MAPK13 (0.46) | MAPK13MAPK11CYP2C9MAPK12MAPK14 | |
| SCHEMBL5807489 | 0.71 | MAPK13 (0.53) | MAPK13MAPK11CYP2C9MEN1KMT2A | |
| SCHEMBL5808420 | 0.68 | MAPK11 (0.54) | MAPK13MAPK11CYP2C9ALDH1A1MAPK12 | |
| SCHEMBL5812295 | 0.68 | MAPK13 (0.53) | MAPK13MAPK11CYP2C9MEN1KMT2A | |
| SCHEMBL5813188 | 0.67 | MAPK11 (0.42) | MAPK13MAPK11CYP2C9MEN1KMT2A | |
| SCHEMBL27735800 | 0.66 | TSHR (0.43) | MAPK13MAPK11CYP2C9MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101268079-B | Pyridazinone derivatives for the treatment of pain | ASTELLAS PHARMA INC | 2011-09-14 | — | — | CN | disclosed |
| CN-101268079-A | Pyridazinone derivatives for the treatment of pain | ASTELLAS PHARMA INC (JP) | 2008-09-17 | — | — | CN | disclosed |