Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27714968 | 0.95 | MAPK13 (0.42) | MAPK13CYP2C9MAPK11HDAC1MEN1 | |
| SCHEMBL4236904 | 0.89 | MAPK13 (0.52) | MAPK13CYP2C9MAPK11HDAC6HDAC1 | |
| SCHEMBL4243533 | 0.84 | MAPK13 (0.53) | MAPK13CYP2C9MAPK11MEN1KMT2A | |
| SCHEMBL5807489 | 0.74 | MAPK13 (0.53) | MAPK13CYP2C9MAPK11HDAC6MEN1 | |
| SCHEMBL4246034 | 0.73 | MAPK13 (0.48) | MAPK13CYP2C9MAPK11MEN1KMT2A | |
| SCHEMBL27819208 | 0.72 | MAPK13 (0.46) | MAPK13CYP2C9MAPK11ADORA1 | |
| SCHEMBL5811657 | 0.67 | MAPK11 (0.54) | MAPK13CYP2C9MAPK11HDAC6MEN1 | |
| SCHEMBL4240237 | 0.67 | MAPK11 (0.58) | MAPK13CYP2C9MAPK11HDAC6ADORA1 | |
| SCHEMBL5808420 | 0.67 | MAPK11 (0.54) | MAPK13CYP2C9MAPK11ADORA1 | |
| SCHEMBL5812295 | 0.67 | MAPK13 (0.53) | MAPK13CYP2C9MAPK11MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101268079-B | Pyridazinone derivatives for the treatment of pain | ASTELLAS PHARMA INC | 2011-09-14 | — | — | CN | disclosed |
| CN-101268079-A | Pyridazinone derivatives for the treatment of pain | ASTELLAS PHARMA INC (JP) | 2008-09-17 | — | — | CN | disclosed |