Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27736156 | 0.92 | KMT2A (0.43) | KMT2AHTTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL3978060 | 0.82 | KMT2A (0.50) | KMT2AHTTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL3978337 | 0.81 | KMT2A (0.54) | KMT2AHTTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL3979100 | 0.75 | NPSR1 (0.60) | HTTSMN1; SMN2L3MBTL1GAATSHR | |
| SCHEMBL3979034 | 0.74 | GABRA5 (0.51) | KMT2AGAATSHRP2RY12GABRA5 | |
| SCHEMBL3975394 | 0.72 | HTT (0.61) | KMT2AHTTSMN1; SMN2LMNAGABRA5 | |
| SCHEMBL3975360 | 0.72 | NPC1 (0.48) | KMT2ALMNAMEN1TSHRP2RY12 | |
| SCHEMBL3979026 | 0.72 | TRPV1 (0.45) | KMT2AHTTMEN1TSHRP2RY12 | |
| SCHEMBL3976838 | 0.72 | GABRA5 (0.51) | KMT2AGAATSHRP2RY12GABRA5 | |
| SCHEMBL3976772 | 0.72 | GPBAR1 (0.46) | KMT2AHTTSMN1; SMN2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101263139-A | Isoxazolo derivatives as GABA A alpha5 inverse agonists | HOFFMANN LA ROCHE (CH) | 2008-09-10 | — | — | CN | claimed |
| CN-101263139-A | Isoxazolo derivatives as GABA A alpha5 inverse agonists | HOFFMANN LA ROCHE (CH) | 2008-09-10 | — | — | CN | disclosed |