Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.60 |
| ▸ | HTR2C | P28335 | 4/20 | 0.60 |
| ▸ | HTR1A | P08908 | 3/20 | 0.60 |
| ▸ | HTR2B | P41595 | 3/20 | 0.60 |
| ▸ | HTR1B | P28222 | 3/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | HTR1D | P28221 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | PTPRA | P18433 | 1/20 | 0.60 |
| ▸ | NQO2 | P16083 | 1/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | HTR1E | P28566 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | HTR6 | P50406 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16366296 | 0.90 | PTPRA (0.73) | HTR2AHTR2CHTR1AHTR2BHTR1B | |
| SCHEMBL22316600 | 0.90 | PTPRA (0.73) | HTR2AHTR2CHTR1AHTR2BHTR1B | |
| SCHEMBL10580344 | 0.86 | NQO2 (0.56) | CYP2C19PTPRANQO2SLC6A4PKM | |
| SCHEMBL5115727 | 0.83 | PTPRA (0.67) | HTR2AHTR2CHTR1AHTR2BCYP2C19 | |
| SCHEMBL1580112 | 0.83 | PTPRA (0.82) | HTR2AHTR2CHTR1AHTR2BCYP2C19 | |
| SCHEMBL5115733 | 0.83 | PTPRA (0.67) | HTR2AHTR2CHTR1AHTR2BCYP2C19 | |
| SCHEMBL14032218 | 0.83 | PTPRA (0.60) | CYP2C19PTPRANQO2 | |
| SCHEMBL1580111 | 0.83 | PTPRA (0.82) | HTR2AHTR2CHTR1AHTR2BCYP2C19 | |
| SCHEMBL3294986 | 0.83 | NQO2 (0.64) | HTR2ANQO2SLC6A4PKMPKLR | |
| SCHEMBL5773295 | 0.82 | PTPRA (0.61) | HTR2AHTR2CHTR1AHTR2BCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101272785-A | Tetrahydro- beta-carbolin-sulfonamide derivatives as 5-HT6 ligands | ESTEVE LABOR DR (ES) | 2008-09-24 | — | — | CN | disclosed |