Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MASP2 | O00187 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.34 |
| ▸ | CHRNG | P07510 | 1/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27556457 | 0.88 | POLB (0.40) | KDM4EPOLBL3MBTL1GAAKMT2A | |
| SCHEMBL27685360 | 0.81 | PTPN1 (0.39) | L3MBTL1USP2 | |
| SCHEMBL28274463 | 0.81 | ALDH1A1 (0.42) | KDM4EL3MBTL1USP2ALDH1A1MAPT | |
| SCHEMBL27459025 | 0.79 | HPGD (0.33) | ALDH1A1MAPT | |
| SCHEMBL27859196 | 0.78 | BRD4 (0.44) | RECQL | |
| SCHEMBL27590553 | 0.78 | BRD4 (0.36) | KDM4EPOLBL3MBTL1GAAKMT2A | |
| SCHEMBL27590550 | 0.74 | MAOB (0.33) | KDM4EKMT2AMAPT | |
| SCHEMBL27539125 | 0.74 | — | — | |
| SCHEMBL27488773 | 0.74 | AHR (0.35) | POLBKMT2AMAPTMEN1CYP2A6 | |
| SCHEMBL27590615 | 0.74 | AHR (0.35) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101679401-B | 2-oxo-3-benzyl-benzoxazol-2-one derivatives and related compounds as MET kinase inhibitors for the treatment of tumors | MERCK PATENT GMBH | 2012-12-12 | — | — | CN | disclosed |
| CN-101679401-A | 2-oxo-3-benzyl-benzoxazol-2-one derivatives and related compounds as MET kinase inhibitors for the treatment of tumors | MERCK PATENT GMBH | 2010-03-24 | — | — | CN | disclosed |
| CN-101208315-A | Benzooxazol-2-one derivatives as lipase and phospholipase inhibitors | SANOFI AVENTIS (FR) | 2008-06-25 | — | — | CN | disclosed |