Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27699684 | 0.81 | ALOX5 (0.56) | ALOX5HPGDALDH1A1KDM4ELMNA | |
| SCHEMBL4078588 | 0.77 | ALOX5 (0.55) | ALOX5HPGDALDH1A1KDM4ELMNA | |
| SCHEMBL756410 | 0.75 | GRM2 (0.53) | ALOX5GRM2 | |
| SCHEMBL4075997 | 0.75 | ALOX5 (0.57) | ALOX5HPGDALDH1A1KDM4ELMNA | |
| SCHEMBL27720327 | 0.74 | ALOX5 (0.49) | ALOX5HPGDALDH1A1KDM4ELMNA | |
| SCHEMBL27699702 | 0.74 | ALOX5 (0.44) | ALOX5HPGDALDH1A1KDM4ELMNA | |
| SCHEMBL27720330 | 0.73 | ALOX5 (0.55) | ALOX5HPGDALDH1A1KDM4ELMNA | |
| SCHEMBL28768571 | 0.73 | ALOX5 (0.47) | ALOX5HPGDALDH1A1LMNAGRM2 | |
| SCHEMBL27699850 | 0.72 | ALOX5 (0.46) | ALOX5HPGDALDH1A1KDM4ELMNA | |
| SCHEMBL27699772 | 0.72 | ALOX5 (0.44) | ALOX5HPGDALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101146802-A | Thiadiazole-substituted coumarin derivatives and their use as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA LTD (CA) | 2008-03-19 | — | — | CN | claimed |