Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.60 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078102 | 0.87 | ALOX5 (0.68) | ALOX5KMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL4088580 | 0.85 | ALOX5 (0.68) | ALOX5KMT2AMEN1TDP1ALDH1A1 | |
| SCHEMBL4083470 | 0.84 | ALOX5 (0.60) | ALOX5KCNA3KMT2AMEN1TDP1 | |
| SCHEMBL4080760 | 0.84 | ALOX5 (0.67) | ALOX5TDP1ALDH1A1HPGDKDM4E | |
| SCHEMBL4080470 | 0.84 | ALOX5 (0.82) | ALOX5KMT2AMEN1TDP1ALDH1A1 | |
| SCHEMBL4082361 | 0.82 | ALOX5 (0.62) | ALOX5KCNA3KMT2AMEN1ALDH1A1 | |
| SCHEMBL4083429 | 0.82 | ALOX5 (0.68) | ALOX5KMT2AALDH1A1HPGDUSP2 | |
| SCHEMBL27720346 | 0.81 | ALOX5 (0.60) | ALOX5KMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL4084878 | 0.80 | ALOX5 (0.61) | ALOX5KCNA3KMT2AMEN1ALDH1A1 | |
| SCHEMBL4076109 | 0.80 | ALOX5 (0.58) | ALOX5TDP1ALDH1A1HPGDUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101146802-A | Thiadiazole-substituted coumarin derivatives and their use as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA LTD (CA) | 2008-03-19 | — | — | CN | disclosed |