Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 10/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2771623 | 0.92 | NR1H4 (0.46) | MRGPRX4NR1H4PPARANR4A2S1PR1 | |
| SCHEMBL2771176 | 0.91 | NR1H4 (0.61) | MRGPRX4NR1H4PPARA | |
| SCHEMBL2773812 | 0.86 | MRGPRX4 (0.48) | MRGPRX4NR1H4PPARANPC1NR4A2 | |
| SCHEMBL3155316 | 0.86 | MRGPRX4 (0.47) | MRGPRX4NR1H4PPARANR4A2S1PR1 | |
| SCHEMBL2775204 | 0.85 | MRGPRX4 (0.47) | MRGPRX4NR1H4PPARANPC1NR4A2 | |
| SCHEMBL498490 | 0.85 | NR1H4 (0.62) | MRGPRX4NR1H4PPARA | |
| SCHEMBL2773885 | 0.84 | NR1H4 (0.59) | MRGPRX4NR1H4PPARA | |
| SCHEMBL2770433 | 0.84 | MRGPRX4 (0.47) | MRGPRX4NR1H4PPARANPC1NR4A2 | |
| SCHEMBL2770618 | 0.84 | NR1H4 (0.58) | MRGPRX4NR1H4PPARAS1PR1S1PR5 | |
| SCHEMBL2772150 | 0.83 | MRGPRX4 (0.52) | MRGPRX4NR1H4BCL2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |