Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 12/20 | 0.59 |
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | LIFR | P42702 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2772215 | 0.93 | NR1H4 (0.56) | NR1H4MRGPRX4PPARALIFR | |
| SCHEMBL2771176 | 0.93 | NR1H4 (0.61) | NR1H4MRGPRX4PPARALIFR | |
| SCHEMBL2773434 | 0.89 | NR1H4 (0.54) | NR1H4MRGPRX4PPARA | |
| SCHEMBL2770618 | 0.88 | NR1H4 (0.58) | NR1H4MRGPRX4PPARALIFR | |
| SCHEMBL2772745 | 0.88 | NR1H4 (0.53) | NR1H4MRGPRX4PPARA | |
| SCHEMBL2771368 | 0.87 | NR1H4 (0.59) | NR1H4MRGPRX4PPARALIFR | |
| SCHEMBL2773673 | 0.86 | NR1H4 (0.47) | NR1H4PPARA | |
| SCHEMBL2770317 | 0.86 | NR1H4 (0.68) | NR1H4MRGPRX4LIFR | |
| SCHEMBL2771059 | 0.85 | NR1H4 (0.57) | NR1H4MRGPRX4PPARA | |
| SCHEMBL2771221 | 0.85 | NR1H4 (0.62) | NR1H4MRGPRX4LIFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |