Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.64 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.64 |
| ▸ | HTR3B | O95264 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | HTR3A | P46098 | 2/20 | 0.64 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.64 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.64 |
| ▸ | THPO | P40225 | 1/20 | 0.64 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29931500 | 0.89 | KDM4E (0.68) | KDM4EALDH1A1SMN1; SMN2HRH3HTR3E | |
| SCHEMBL5239212 | 0.89 | KDM4E (0.68) | KDM4EALDH1A1SMN1; SMN2HRH3HTR3E | |
| SCHEMBL20274109 | 0.85 | KDM4E (0.66) | KDM4EALDH1A1SMN1; SMN2HRH3HTR3E | |
| SCHEMBL27722989 | 0.82 | KDM4E (0.66) | KDM4EALDH1A1SMN1; SMN2HRH3HTR3E | |
| SCHEMBL11081503 | 0.82 | KDM4E (0.62) | KDM4EALDH1A1SMN1; SMN2HRH3HTR3E | |
| SCHEMBL3590893 | 0.81 | ALDH1A1 (0.77) | KDM4EALDH1A1SMN1; SMN2HCAR2MAPK1 | |
| SCHEMBL4055019 | 0.81 | PDE10A (0.64) | KDM4EALDH1A1SMN1; SMN2HRH3HTR3E | |
| SCHEMBL30824499 | 0.79 | HRH3 (0.71) | KDM4EALDH1A1SMN1; SMN2HRH3HTR3E | |
| SCHEMBL5664122 | 0.79 | HRH3 (0.71) | KDM4EALDH1A1SMN1; SMN2HRH3HTR3E | |
| SCHEMBL29604668 | 0.79 | HRH3 (0.71) | KDM4EALDH1A1SMN1; SMN2HRH3HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101193635-A | Multicyclic compounds and methods of their use | LEXICON GENETICS INC (US) | 2008-06-04 | — | — | CN | claimed |
| CN-101193635-A | Multicyclic compounds and methods of their use | LEXICON GENETICS INC (US) | 2008-06-04 | — | — | CN | disclosed |