Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | BLVRB | P30043 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 3/20 | 0.43 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28227720 | 0.87 | TTR (0.44) | KDM5AKDM4CKDM5BMAOABLVRB | |
| SCHEMBL28654565 | 0.85 | CDC7 (0.50) | KDM5AKDM4CKDM5BFFAR1NPC1 | |
| SCHEMBL21666674 | 0.85 | CDC7 (0.37) | KDM5AKDM4CKDM5BMAOABLVRB | |
| SCHEMBL21239294 | 0.83 | KDM5A (0.35) | KDM5AKDM4CKDM5BMAOABLVRB | |
| SCHEMBL29815918 | 0.81 | NPC1 (0.49) | NPC1RAB9ATSHR | |
| SCHEMBL31647020 | 0.81 | GAA (0.46) | HDAC6 | |
| SCHEMBL27743999 | 0.80 | ALDH1A1 (0.47) | TTRNOTUMFFAR1 | |
| SCHEMBL29237107 | 0.79 | TDP1 (0.51) | NPC1RAB9APTGER1TSHR | |
| SCHEMBL30267515 | 0.78 | JAK2 (0.49) | RAB9ATSHR | |
| SCHEMBL1156246 | 0.78 | JAK2 (0.49) | RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108148044-B | Amide compound and method for preparing Vonoprazan fumarate from same | 上海医药工业研究院 | 2024-05-14 | — | — | CN | claimed |
| CN-118978468-A | Synthesis method of voronoi fumarate intermediate | 武汉软件工程职业学院(武汉开放大学) | 2024-11-19 | — | — | CN | disclosed |
| CN-108148044-B | Amide compound and method for preparing Vonoprazan fumarate from same | 上海医药工业研究院 | 2024-05-14 | — | — | CN | disclosed |
| CN-107915720-B | Novel preparation method of Vonoprazan | 常州市第四制药厂有限公司 | 2020-09-11 | — | — | CN | disclosed |
| CN-109843869-A | 1- [(pyridin-3-yl-sulfonyl) -1H- pyrroles -3- base] methylamine derivative and its pharmaceutical composition and purposes | 江苏吉贝尔药业股份有限公司 | 2019-06-04 | — | — | CN | disclosed |
| CN-101300229-B | 1-heterocyclylsulfonyl, 2-aminomethyl, 5- (hetero-) aryl substituted 1-h-pyrrole derivatives as acid secretion inhibitors | TAKEDA PHARMACEUTICAL | 2011-10-05 | — | — | CN | disclosed |
| CN-101300229-A | 1-heterocyclylsulfonyl, 2-aminomethyl, 5- (hetero-) aryl substituted 1-h-pyrrole derivatives as acid secretion inhibitors | TAKEDA PHARMACEUTICAL (JP) | 2008-11-05 | — | — | CN | disclosed |