Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 14/20 | 0.66 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | PRKCG | P05129 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | AKT2 | P31751 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.45 |
| ▸ | PRKX | P51817 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4519261 | 1.00 | ROCK2 (0.66) | ROCK2ROCK1MAPK1MAPK13RPS6KA5 | |
| SCHEMBL4531189 | 0.83 | ROCK2 (0.70) | ROCK2ROCK1MAPK1MAPK13RPS6KA5 | |
| SCHEMBL16227497 | 0.80 | ROCK2 (1.00) | ROCK2ROCK1MAPK1MAPK13RPS6KA5 | |
| SCHEMBL4531729 | 0.80 | ROCK2 (1.00) | ROCK2ROCK1MAPK1MAPK13RPS6KA5 | |
| SCHEMBL4533393 | 0.80 | ROCK2 (1.00) | ROCK2ROCK1MAPK1MAPK13RPS6KA5 | |
| SCHEMBL4529608 | 0.77 | AAK1 (0.49) | ROCK2ROCK1MAP4K4AKT1IRAK1 | |
| SCHEMBL4530746 | 0.76 | ROCK2 (0.44) | ROCK2ROCK1TRPV1 | |
| SCHEMBL4522397 | 0.74 | ROCK2 (0.68) | ROCK2ROCK1MAPK1MAPK13RPS6KA5 | |
| SCHEMBL4526995 | 0.74 | ROCK2 (0.68) | ROCK2ROCK1MAPK1MAPK13RPS6KA5 | |
| SCHEMBL27723721 | 0.74 | ROCK2 (0.68) | ROCK2ROCK1MAPK1MAPK13RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101253152-A | Amide derivatives as ROCK inhibitors | ASTELLAS PHARMA INC (JP) | 2008-08-27 | — | — | CN | disclosed |