Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 13/20 | 0.39 |
| ▸ | KIT | P10721 | 5/20 | 0.39 |
| ▸ | FLT3 | P36888 | 4/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.37 |
| ▸ | LCK | P06239 | 3/20 | 0.37 |
| ▸ | CSF1R | P07333 | 3/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.37 |
| ▸ | PRKACA | P17612 | 3/20 | 0.37 |
| ▸ | AURKA | O14965 | 3/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.37 |
| ▸ | PLK4 | O00444 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | LYN | P07948 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | MARK3 | P27448 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11498709 | 0.84 | GSK3B (0.58) | GSK3BKDRKITFLT3LRRK2 | |
| SCHEMBL2235173 | 0.84 | KDR (0.55) | GSK3BKDRKITFLT3LRRK2 | |
| SCHEMBL6116348 | 0.76 | BTK (0.53) | GSK3B | |
| SCHEMBL23780027 | 0.73 | KDR (0.71) | GSK3BKDRKITFLT3LRRK2 | |
| SCHEMBL18613518 | 0.72 | FYN (0.48) | KDRKITLRRK2STK3 | |
| SCHEMBL5265515 | 0.71 | KDR (0.39) | GSK3BKDRKITFLT3LRRK2 | |
| SCHEMBL1703315 | 0.71 | KDR (0.70) | GSK3BKDRKITFLT3ROCK1 | |
| SCHEMBL28813094 | 0.69 | GAA (0.50) | GSK3BKDRFLT3LRRK2ROCK1 | |
| SCHEMBL16680727 | 0.69 | NOS2 (0.45) | GSK3BKDRROCK1PRKACAAURKA | |
| SCHEMBL1585572 | 0.69 | PRKCI (0.40) | GSK3BKDRROCK1LCKCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101146534-A | Substituted pyrazolopyridines, compositions containing them, method for the production thereof, and their use | AVENTIS PHARMA SA (FR) | 2008-03-19 | — | — | CN | disclosed |