Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 7/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4350194 | 0.92 | CHEK1 (0.53) | CHEK1KCNH2PRMT5KMT2A | |
| SCHEMBL4342206 | 0.82 | CHEK1 (0.73) | CHEK1KCNH2 | |
| SCHEMBL4341478 | 0.70 | CHEK1 (0.51) | CHEK1KCNH2JAK2JAK1 | |
| SCHEMBL4943046 | 0.69 | PRMT5 (0.47) | PRMT5GPR119TLR9TLR7USP30 | |
| SCHEMBL7166480 | 0.69 | PRMT5 (0.46) | PRMT5GPR119TLR9TLR7USP30 | |
| SCHEMBL31020047 | 0.68 | PRMT5 (0.45) | PRMT5GPR119TLR9TLR7USP30 | |
| SCHEMBL14046479 | 0.68 | PRMT5 (0.48) | PRMT5GPR119TLR9TLR7USP30 | |
| SCHEMBL4946466 | 0.68 | PRMT5 (0.47) | PRMT5GPR119TLR9TLR7USP30 | |
| SCHEMBL18497731 | 0.68 | IRAK4 (0.46) | PRMT5TLR9TLR7 | |
| SCHEMBL18497732 | 0.68 | IRAK4 (0.46) | PRMT5TLR9TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101189243-A | Substituted heterocycles and their use as CHK1, PDK1 and PAK inhibitors | ASTRAZENECA AB (SE) | 2008-05-28 | — | — | CN | disclosed |