Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 20/20 | 0.67 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.67 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.67 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.67 |
| ▸ | KLKB1 | P03952 | 7/20 | 0.63 |
| ▸ | F7 | P08709 | 3/20 | 0.63 |
| ▸ | F10 | P00742 | 2/20 | 0.63 |
| ▸ | F12 | P00748 | 2/20 | 0.63 |
| ▸ | KLK1 | P06870 | 2/20 | 0.63 |
| ▸ | PLG | P00747 | 1/20 | 0.63 |
| ▸ | PLAT | P00750 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1195921 | 1.00 | F11 (0.67) | F11PRSS1PRSS2PRSS3KLKB1 | |
| SCHEMBL12011606 | 0.94 | F11 (0.67) | F11PRSS1PRSS2PRSS3KLKB1 | |
| SCHEMBL1196225 | 0.93 | F11 (0.68) | F11PRSS1PRSS2PRSS3KLKB1 | |
| SCHEMBL27745707 | 0.93 | F11 (0.68) | F11PRSS1PRSS2PRSS3KLKB1 | |
| SCHEMBL12011675 | 0.93 | F11 (0.57) | F11PRSS1PRSS2PRSS3KLKB1 | |
| SCHEMBL1197072 | 0.93 | F11 (0.69) | F11PRSS1PRSS2PRSS3KLKB1 | |
| SCHEMBL1197156 | 0.93 | F11 (0.69) | F11PRSS1PRSS2PRSS3KLKB1 | |
| SCHEMBL27724979 | 0.93 | F11 (0.69) | F11PRSS1PRSS2PRSS3KLKB1 | |
| SCHEMBL1197165 | 0.92 | F11 (0.64) | F11PRSS1PRSS2PRSS3KLKB1 | |
| SCHEMBL27745633 | 0.91 | F11 (0.67) | F11PRSS1PRSS2PRSS3KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101341129-B | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors | BRISTOL-MYERS SQUIBB CO. (US) | 2011-12-14 | — | — | CN | disclosed |
| CN-101341129-A | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2009-01-07 | — | — | CN | disclosed |