Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 13/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.38 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27704569 | 0.93 | RAB9A (0.43) | HDAC1HDAC8HDAC6HDAC4HDAC3 | |
| SCHEMBL3135033 | 0.85 | CAPN1 (0.45) | HDAC1HDAC8HDAC6HDAC4HDAC3 | |
| SCHEMBL3135026 | 0.85 | CAPN1 (0.45) | HDAC1HDAC8HDAC6HDAC4HDAC3 | |
| SCHEMBL27704601 | 0.84 | HDAC1 (0.51) | HDAC1HDAC8HDAC6HDAC4HDAC3 | |
| SCHEMBL3144397 | 0.79 | HDAC1 (0.51) | HDAC1HDAC8HDAC6HDAC4HDAC3 | |
| SCHEMBL3144410 | 0.79 | HDAC1 (0.51) | HDAC1HDAC8HDAC6HDAC4HDAC3 | |
| SCHEMBL3145299 | 0.78 | HDAC1 (0.52) | HDAC1HDAC8HDAC6HDAC4HDAC3 | |
| SCHEMBL3145314 | 0.78 | HDAC1 (0.52) | HDAC1HDAC8HDAC6HDAC4HDAC3 | |
| SCHEMBL27704595 | 0.77 | HDAC1 (0.58) | HDAC1HDAC8HDAC6HDAC4HDAC3 | |
| SCHEMBL27725095 | 0.77 | HDAC1 (0.44) | HDAC1HDAC8HDAC6HDAC4HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101137623-B | N-sulphonylpyrroles and use thereof as histone deacetylase inhibitors | NYCOMED GMBH | 2013-03-27 | — | — | CN | claimed |
| CN-101137623-A | N-sulphonylpyrroles and their use as histone deacetylase inhibitors | NYCOMED GMBH (DE) | 2008-03-05 | — | — | CN | claimed |
| CN-101137623-B | N-sulphonylpyrroles and use thereof as histone deacetylase inhibitors | NYCOMED GMBH | 2013-03-27 | — | — | CN | disclosed |
| CN-101137623-A | N-sulphonylpyrroles and their use as histone deacetylase inhibitors | NYCOMED GMBH (DE) | 2008-03-05 | — | — | CN | disclosed |