Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 2/20 | 0.43 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4157069 | 0.86 | CYP1A2 (0.48) | NOTUMCYP1A2ELANELMNAMAPT | |
| SCHEMBL5752612 | 0.86 | NOTUM (0.76) | NOTUMPOLBCYP1A2ALKBH5ELANE | |
| SCHEMBL29808797 | 0.86 | NOTUM (0.76) | NOTUMPOLBCYP1A2ALKBH5ELANE | |
| SCHEMBL8065166 | 0.83 | NOTUM (0.65) | NOTUMPOLBCYP1A2CFTRALKBH5 | |
| SCHEMBL984085 | 0.82 | NOTUM (0.64) | NOTUMPOLBCYP1A2CFTRALKBH5 | |
| SCHEMBL4152306 | 0.81 | NOTUM (0.62) | NOTUMPOLBCYP1A2ALKBH5ELANE | |
| SCHEMBL560810 | 0.81 | NOTUM (0.61) | NOTUMPOLBCYP1A2CFTRALKBH5 | |
| SCHEMBL8063220 | 0.81 | NOTUM (0.61) | NOTUMPOLBCYP1A2ALKBH5ELANE | |
| SCHEMBL8236829 | 0.80 | NOTUM (0.60) | NOTUMPOLBCYP1A2ALKBH5ELANE | |
| SCHEMBL4022781 | 0.80 | NOTUM (0.63) | NOTUMPOLBCYP1A2ALKBH5ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101142189-A | 2-pyridine derivatives as inhibitors of neutrophile elastase | ASTRAZENECA AB (SE) | 2008-03-12 | — | — | CN | disclosed |