Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 2/20 | 0.45 |
| ▸ | CFTR | P13569 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.42 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752612 | 0.90 | NOTUM (0.76) | NOTUMPOLBCYP1A2ALKBH5ELANE | |
| SCHEMBL29808797 | 0.90 | NOTUM (0.76) | NOTUMPOLBCYP1A2ALKBH5ELANE | |
| SCHEMBL984085 | 0.86 | NOTUM (0.64) | NOTUMPOLBCYP1A2ALKBH5ELANE | |
| SCHEMBL4152306 | 0.85 | NOTUM (0.62) | NOTUMPOLBCYP1A2ALKBH5ELANE | |
| SCHEMBL560810 | 0.84 | NOTUM (0.61) | NOTUMPOLBCYP1A2ALKBH5ELANE | |
| SCHEMBL8063220 | 0.84 | NOTUM (0.61) | NOTUMPOLBCYP1A2ALKBH5ELANE | |
| SCHEMBL4022781 | 0.83 | NOTUM (0.63) | NOTUMPOLBCYP1A2ALKBH5ELANE | |
| SCHEMBL27725852 | 0.83 | NOTUM (0.60) | NOTUMPOLBCYP1A2ALKBH5ELANE | |
| SCHEMBL8236829 | 0.83 | NOTUM (0.60) | NOTUMPOLBCYP1A2ALKBH5ELANE | |
| SCHEMBL4021502 | 0.82 | NOTUM (0.59) | NOTUMPOLBCYP1A2ALKBH5ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009037413-A1 | DIMERS OF 5- [ (4-CYANOPHENYL) SULFINYL] -6-METHYL-2-OXO-1- [3- (TRIFLUOROMETHYL)PHENYL] -1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE AS INHIBITORS OF HUMAN NEUTROPHIL ELASTASE FOR TREATING RESPIRATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-03-26 | — | — | WO | disclosed |
| WO-2007107706-A2 | DIMERS OF HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF COPD | ARGENTA DISCOVERY LIMITED (GB) | 2007-09-27 | — | — | WO | disclosed |