Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 12/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 12/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 12/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27617934 | 0.88 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL5008335 | 0.87 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11GAA | |
| SCHEMBL27749277 | 0.82 | CYP2C8 (0.48) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL5007743 | 0.81 | CLCN2 (0.51) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL27637095 | 0.80 | ADORA1 (0.51) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27637099 | 0.80 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL28759610 | 0.79 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL28754595 | 0.78 | ADORA1 (0.42) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27617939 | 0.78 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL28757654 | 0.78 | MAPK14 (0.42) | MAPK14MAPK13MAPK12MAPK11JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100448869-C | Anilinopyrazole derivatives for the treatment of diabetes | BAYER PHARMACEUTICALS CORP (US) | 2009-01-07 | — | — | CN | disclosed |