Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | MGAM | O43451 | 1/20 | 0.55 |
| ▸ | SI | P14410 | 1/20 | 0.55 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | MAT2A | P31153 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7504407 | 0.82 | GAA (1.00) | GAAMAPTKMT2AKDM4EHPGD | |
| SCHEMBL16682868 | 0.81 | MAPK1 (0.69) | GAAMAPTKMT2AKDM4EHPGD | |
| SCHEMBL21185316 | 0.76 | MAPT (0.53) | GAAMAPTKMT2AKDM4EHPGD | |
| SCHEMBL30133175 | 0.76 | MGAM (0.51) | GAAMGAMSIMGAM2PTPN1 | |
| SCHEMBL26292599 | 0.73 | MAPT (0.58) | GAAMAPTKMT2AKDM4EHSD17B10 | |
| SCHEMBL11369393 | 0.72 | HSD17B2 (0.58) | GAAMGAMSIMGAM2HSD17B1 | |
| SCHEMBL7392811 | 0.71 | GUSB (0.73) | GAAMAPTKDM4EHPGDMGAM | |
| SCHEMBL10369738 | 0.70 | MAPK1 (0.67) | GAAMAPTKMT2AKDM4EHPGD | |
| SCHEMBL873906 | 0.70 | TNKS (0.71) | MAPTKDM4EHPGDHSD17B10PARP1 | |
| SCHEMBL31087977 | 0.69 | SMPD3 (0.51) | GAAMGAMSIMGAM2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101360498-A | Calcilytic compounds | SMITHKLINE BEECHAM CORP (US) | 2009-02-04 | — | — | CN | disclosed |