Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 13/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 13/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27710175 | 0.90 | NR1H2 (0.49) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407763 | 0.88 | NR1H2 (0.52) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL27730657 | 0.83 | NR1H2 (0.66) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1408271 | 0.82 | NR1H2 (0.49) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407451 | 0.78 | NR1H2 (0.68) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL27710163 | 0.78 | NR1H2 (0.55) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL3860965 | 0.77 | NR1H3 (0.82) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407178 | 0.77 | NR1H2 (0.50) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407404 | 0.76 | NR1H2 (0.62) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407301 | 0.75 | NR1H2 (0.74) | NR1H2NR1H3NR1I2NR3C1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101213194-A | Indazoles useful in treating cardiovascular diseases | WYETH CORP (US) | 2008-07-02 | — | — | CN | claimed |
| CN-101213194-A | Indazoles useful in treating cardiovascular diseases | WYETH CORP (US) | 2008-07-02 | — | — | CN | disclosed |