Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.40 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5269496 | 0.98 | NPC1 (0.50) | NPC1RAB9AMAPTPOLBCYP2C9 | |
| Iodide SCHEMBL2920576 | 0.86 | NPC1 (0.51) | NPC1RAB9AMAPTPOLBCYP2C9 | |
| SCHEMBL5269493 | 0.84 | NPC1 (0.53) | NPC1RAB9AMAPTPOLBCYP2C9 | |
| SCHEMBL10180412 | 0.82 | NPC1 (0.51) | NPC1RAB9AMAPTPOLBCYP2C9 | |
| SCHEMBL10182176 | 0.82 | NPC1 (0.51) | NPC1RAB9AMAPTPOLBCYP2C9 | |
| SCHEMBL10180126 | 0.81 | NPC1 (0.51) | NPC1RAB9AMAPTPOLBCYP2C9 | |
| SCHEMBL5270879 | 0.81 | NPC1 (0.50) | NPC1RAB9AMAPTPOLBCYP2C9 | |
| SCHEMBL22518676 | 0.81 | NPC1 (0.50) | NPC1RAB9AMAPTPOLBCYP2C9 | |
| SCHEMBL10625087 | 0.80 | CA2 (0.50) | MAPTPOLBCA1CA2CA9 | |
| SCHEMBL5269351 | 0.80 | CA1 (0.66) | NPC1RAB9AMAPTCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117002-B1 | Negative-working resist composition | FUJIFILM CORP (JP) | 2010-04-14 | — | — | EP | disclosed |
| US-6720128-B2 | AMPLIFICATION; ACCURACY PATTERN PROFILE; EXPOSURE TO ELECTRON BEAMS | FUJI PHOTO FILM CO., LTD. (JP) | 2004-04-13 | — | — | US | disclosed |
| EP-1117004-A2 | Electron beam or x-ray negative-working resist composition | FUJI PHOTO FILM CO., LTD. (JP) | 2001-07-18 | — | — | EP | disclosed |
| EP-1117002-A1 | Negative-working resist composition | FUJI PHOTO FILM CO., LTD. (JP) | 2001-07-18 | — | — | EP | disclosed |