Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 1/20 | 0.39 |
| ▸ | MAPK7 | Q13164 | 12/20 | 0.37 |
| ▸ | PRKDC | P78527 | 4/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966092 | 0.92 | KHK (0.41) | KHKMAPK7PRKDCKITACVR1 | |
| SCHEMBL3570349 | 0.87 | MAPK7 (0.39) | KHKMAPK7PRKDCKITACVR1 | |
| SCHEMBL3566238 | 0.85 | ACVR1 (0.45) | KHKMAPK7PRKDCACVR1 | |
| SCHEMBL4962579 | 0.84 | MAPK7 (0.43) | MAPK7PRKDCCSF1R | |
| SCHEMBL3562983 | 0.84 | MAPK7 (0.40) | KHKMAPK7KIT | |
| SCHEMBL27732304 | 0.82 | MAPK7 (0.41) | MAPK7PRKDC | |
| SCHEMBL3566306 | 0.82 | SMN1; SMN2 (0.40) | KHKMAPK7PRKDCKITACVR1 | |
| SCHEMBL5074996 | 0.81 | MAPK7 (0.45) | MAPK7PRKDC | |
| SCHEMBL3570248 | 0.81 | MTNR1B (0.48) | KHKMAPK7KIT | |
| SCHEMBL4964946 | 0.81 | MAPK7 (0.42) | MAPK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101243065-A | Intermediates for the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related synthetic methods | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-13 | — | — | CN | disclosed |