Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.58 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.52 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.50 |
| ▸ | GAK | O14976 | 1/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.50 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.50 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | CCR8 | P51685 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6215190 | 0.86 | KDM4E (0.59) | HTR1AADRA1DADRA1AADRA1BGAK | |
| SCHEMBL8145365 | 0.81 | HTR1A (0.61) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL14243022 | 0.81 | HTR1A (0.54) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL2997568 | 0.80 | HTR1A (0.59) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL15836948 | 0.79 | HTR1A (0.55) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL704734 | 0.79 | TLR8 (0.61) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL201122 | 0.79 | HTR1A (0.58) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL3841526 | 0.79 | HTR1A (0.58) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL2996402 | 0.79 | HTR1A (0.58) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL29362202 | 0.79 | HTR1A (0.58) | HTR1AADRA1DADRA1AADRA1BFERMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101248059-A | Substituted amide derivatives as protein kinase inhibitors | AMGEN INC (US) | 2008-08-20 | — | — | CN | disclosed |