SCHEMBL2773365

SCHEMBL2773365

Cc1c(C)n(Cc2ccccc2)c2c(OCc3ccc(F)cc3)cncc12

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.45
CYP3A4 P08684 3/20 0.45
ALDH1A1 P00352 3/20 0.45
CYP2C9 P11712 2/20 0.45
TSHR P16473 2/20 0.45
USP2 O75604 1/20 0.45
CYP2D6 P10635 2/20 0.45
CYP2C19 P33261 2/20 0.45
SMN1; SMN2 Q16637 3/20 0.44
MAPK1 P28482 2/20 0.43
HPGD P15428 1/20 0.43
MAPT P10636 2/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
TDP1 Q9NUW8 1/20 0.42
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
AOC3 Q16853 1/20 0.41
LMNA P02545 2/20 0.40
FABP4 P15090 1/20 0.40
POLB P06746 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2769479 0.99 ALDH1A1 (0.45) CYP1A2CYP3A4ALDH1A1CYP2C9TSHR
SCHEMBL2770144 0.95 CYP1A2 (0.47) CYP1A2CYP3A4ALDH1A1CYP2C9TSHR
Hydrochloric Acid SCHEMBL2769085 0.94 CYP1A2 (0.47) CYP1A2CYP3A4ALDH1A1CYP2C9TSHR
SCHEMBL2769471 0.92 CYP1A2 (0.45) CYP1A2CYP3A4ALDH1A1CYP2C9TSHR
Hydrochloric Acid SCHEMBL2771198 0.91 CYP1A2 (0.45) CYP1A2CYP3A4ALDH1A1CYP2C9TSHR
SCHEMBL2770150 0.90 MAPK14 (0.44) CYP1A2CYP3A4ALDH1A1CYP2C9TSHR
SCHEMBL2769739 0.90 NPSR1 (0.43) ALDH1A1SMN1; SMN2MAPK1MAPTL3MBTL1
Hydrochloric Acid SCHEMBL2768919 0.89 MAPK14 (0.44) CYP1A2CYP3A4ALDH1A1CYP2C9TSHR
Hydrochloric Acid SCHEMBL2769070 0.89 AOC3 (0.44) ALDH1A1SMN1; SMN2MAPK1MAPTL3MBTL1
SCHEMBL2771493 0.89 MAPT (0.43) CYP1A2CYP3A4ALDH1A1CYP2C9TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1805177-B9 PYRROLO[3,2-C]PYRIDINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2010-09-15 EP claimed
EP-1805177-B1 PYRROLO[3,2-C]PYRIDINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2010-04-28 EP claimed
EP-1805177-A4 PYRROLO[3,2-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2009-07-29 EP claimed
EP-1805177-A1 PYRROLO[3,2-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF Yuhan Corporation (KR) 2007-07-11 EP claimed
WO-2006025715-A1 PYRROLO[3,2-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORPORATION (KR) 2006-03-09 WO claimed
EP-1805177-A4 PYRROLO[3,2-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2009-07-29 EP disclosed
EP-1805177-A1 PYRROLO[3,2-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF Yuhan Corporation (KR) 2007-07-11 EP disclosed
WO-2006025715-A1 PYRROLO[3,2-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORPORATION (KR) 2006-03-09 WO disclosed