Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | SDHB | P21912 | 1/20 | 0.37 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576371 | 0.88 | RXRA (0.69) | RXRANR1H2NR1H3PDK2PTGS2 | |
| SCHEMBL27733833 | 0.81 | RXRA (0.58) | RXRANR1H2NR1H3PDK2PTGS2 | |
| SCHEMBL3580546 | 0.77 | RXRA (0.73) | RXRANR1H2NR1H3PTGS2 | |
| SCHEMBL7844717 | 0.75 | KAT6A (0.53) | NPC1RAB9APDK2AXLKAT6A | |
| SCHEMBL27933864 | 0.75 | RXRA (0.61) | RXRANR1H2NR1H3PTGS2DHODH | |
| SCHEMBL3584351 | 0.72 | NR1H2 (0.81) | RXRANR1H2NR1H3PTGS2 | |
| SCHEMBL3588428 | 0.72 | NR1H2 (0.79) | RXRANR1H2NR1H3PTGS2 | |
| SCHEMBL27915371 | 0.71 | RXRA (0.67) | RXRANR1H2NR1H3PTGS2 | |
| SCHEMBL15988378 | 0.71 | RXRA (0.69) | RXRANR1H2NR1H3PTGS2 | |
| SCHEMBL3576376 | 0.71 | RXRA (0.67) | RXRANR1H2NR1H3PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101248049-B | Imidazole based lxr modulators | EXELIXIS INC | 2013-08-28 | — | — | CN | disclosed |
| CN-101248049-A | Imidazole based LXR modulators | EXELIXIS INC (US) | 2008-08-20 | — | — | CN | disclosed |