Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27747794 | 0.86 | GPR119 (0.66) | GPR119RAB9ATSHRRECQLSMN1; SMN2 | |
| SCHEMBL1069801 | 0.83 | GPR119 (0.74) | GPR119RAB9ATSHRRECQLSMN1; SMN2 | |
| SCHEMBL390747 | 0.82 | GPR119 (0.69) | GPR119RAB9ATSHRRECQLSMN1; SMN2 | |
| SCHEMBL31643339 | 0.82 | GPR119 (0.70) | GPR119RAB9ATSHRRECQLSMN1; SMN2 | |
| SCHEMBL388894 | 0.81 | GPR119 (0.60) | GPR119RAB9ATSHRRECQLSMN1; SMN2 | |
| SCHEMBL387143 | 0.81 | GPR119 (0.80) | GPR119RAB9ATSHRRECQLSMN1; SMN2 | |
| SCHEMBL386607 | 0.80 | GPR119 (0.69) | GPR119RAB9ATSHRRECQLSMN1; SMN2 | |
| SCHEMBL387294 | 0.80 | GPR119 (0.79) | GPR119RAB9ATSHRRECQLSMN1; SMN2 | |
| SCHEMBL389587 | 0.80 | GPR119 (0.79) | GPR119RAB9ATSHRRECQLSMN1; SMN2 | |
| SCHEMBL4528547 | 0.80 | GPR119 (0.58) | GPR119RAB9ATSHRRECQLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101420941-A | Use of GPR119 receptor agonists for increasing bone mass and for treating osteoporosis, and related combination therapies | ARENA PHARM INC (US) | 2009-04-29 | — | — | CN | disclosed |
| CN-101332303-A | Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood glp-1 level | ARENA PHARM INC (US) | 2008-12-31 | — | — | CN | disclosed |