Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | GRK2 | P25098 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL386914 | 0.85 | GPR119 (0.72) | GPR119CHRNA7TSHRRECQLSMN1; SMN2 | |
| SCHEMBL4524278 | 0.84 | TSHR (0.50) | GPR119CHRNA7TSHRRECQLSMN1; SMN2 | |
| SCHEMBL27769053 | 0.82 | DRD4 (0.36) | GPR119CHRNA7LMNAROCK2GRK2 | |
| SCHEMBL5133959 | 0.81 | TSHR (0.68) | GPR119CHRNA7TSHRRECQLSMN1; SMN2 | |
| SCHEMBL1069801 | 0.80 | GPR119 (0.74) | GPR119CHRNA7TSHRRECQLSMN1; SMN2 | |
| SCHEMBL2298624 | 0.78 | NPC1 (0.56) | GPR119CHRNA7TSHRRECQLSMN1; SMN2 | |
| SCHEMBL5133503 | 0.78 | KMT2A (0.61) | TSHRSMN1; SMN2LMNAKCNH2ALDH1A1 | |
| SCHEMBL2292951 | 0.77 | GPR119 (0.49) | GPR119CHRNA7TSHRRECQLSMN1; SMN2 | |
| SCHEMBL2300194 | 0.77 | SMN1; SMN2 (0.50) | GPR119CHRNA7TSHRRECQLSMN1; SMN2 | |
| SCHEMBL4513166 | 0.76 | SMN1; SMN2 (0.73) | TSHRSMN1; SMN2LMNAEPHX2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101332303-A | Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood glp-1 level | ARENA PHARM INC (US) | 2008-12-31 | — | — | CN | disclosed |