Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | PRKACG | P22612 | 1/20 | 0.33 |
| ▸ | PRKACB | P22694 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18930229 | 0.81 | NOS3 (0.41) | NOS3NOS1DPP4KCNH2CACNA1H | |
| Hydrochloric Acid SCHEMBL21144951 | 0.79 | NOS3 (0.40) | NOS3NOS1DPP4KCNH2CACNA1H | |
| Hydrochloric Acid SCHEMBL21144949 | 0.79 | NOS3 (0.40) | NOS3NOS1DPP4KCNH2CACNA1H | |
| SCHEMBL27714562 | 0.77 | TSHR (0.49) | SIGMAR1BDKRB2DPP4TSHR | |
| SCHEMBL3914612 | 0.77 | SKP2 (0.56) | NOS3NOS1SKP2L3MBTL1AR | |
| SCHEMBL19771973 | 0.75 | NOS3 (0.42) | NOS3NOS1CACNA1HARTSHR | |
| SCHEMBL24528788 | 0.73 | NOS3 (0.46) | NOS3NOS1SKP2L3MBTL1TSHR | |
| SCHEMBL16295917 | 0.72 | SLC7A5 (0.53) | NOS3NOS1 | |
| SCHEMBL27735349 | 0.72 | SLC2A1 (0.44) | CACNA1HL3MBTL1ARTSHR | |
| SCHEMBL12763837 | 0.72 | CYP2A6 (0.48) | NOS3NOS1DPP4KCNH2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101277953-A | Atives of 2-aminthiazoles and 2-aminooxazoles, processes for their preparation and their use as pharmaceuticals | SANOFI AVENTIS (FR) | 2008-10-01 | — | — | CN | disclosed |