Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 4/20 | 0.56 |
| ▸ | GABBR1 | Q9UBS5 | 4/20 | 0.56 |
| ▸ | IRAK1 | P51617 | 8/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.45 |
| ▸ | AXL | P30530 | 3/20 | 0.44 |
| ▸ | MERTK | Q12866 | 2/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27714791 | 0.88 | GABBR2 (0.67) | GABBR2GABBR1IRAK1IRAK4AXL | |
| SCHEMBL3118460 | 0.86 | GABBR2 (0.53) | GABBR2GABBR1IRAK1IRAK4AXL | |
| SCHEMBL3112867 | 0.84 | GABBR2 (0.61) | GABBR2GABBR1IRAK1IRAK4AXL | |
| SCHEMBL3117412 | 0.81 | GABBR2 (0.70) | GABBR2GABBR1IRAK1IRAK4AXL | |
| SCHEMBL3123747 | 0.80 | GABBR2 (0.75) | GABBR2GABBR1IRAK1IRAK4AXL | |
| SCHEMBL27714887 | 0.79 | KDM4E (0.40) | ADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL3113855 | 0.78 | ABCG2 (0.55) | GABBR2GABBR1IRAK1IRAK4 | |
| SCHEMBL3118159 | 0.77 | GABBR2 (0.68) | GABBR2GABBR1IRAK1IRAK4AXL | |
| SCHEMBL3120412 | 0.77 | GABBR2 (0.77) | GABBR2GABBR1IRAK1IRAK4 | |
| SCHEMBL3113894 | 0.77 | GABBR2 (0.71) | GABBR2GABBR1IRAK1IRAK4AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101193868-A | Pyrimidine derivatives for the treatment of GABA B mediated nervous system disorders | NOVARTIS AG (CH) | 2008-06-04 | — | — | CN | disclosed |